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Weight Loss drugs, supplements, and products have been growing rapidly in recent years with hundreds of different options now readily available throughout the dieting industry. Most of these products are available to purchase online or in health food stores nationwide.

These products generally come with a minimal risk to your health and can have enormous health benefits for the user, and when combined with regular exercise and a healthy, well-balanced diet, it can become extremely easy to obtain and keep your ideal figure.

However, some people still struggle to reach their goals with tried and tested methods and may need to consider prescription medications, this can be for a wide range of reasons.

Diethylpropion is a prescription medication and this article will provide you with all of the information you need to understand what it is, what it does, the potential side effects, and if it is for you.

What Is Diethylpropion?

Diethylpropion is classed as a sympathomimetic and central nervous system (CNS) stimulant drug similar to phenethylamine, and amphetamine which is usually synthesized from propiophenone by bromination.

It is known by many other trade names and is marketed as an appetite suppressant, however, Diethylpropion is usually only approved on a short-term basis to help manage obesity in patients with an initial body mass index (BMI) of ≥30 kg.

The drug is prescribed in combination with a calorie restrictive diet for patients who have not responded to a regimen of diet and/or exercise alone.

What Does Diethylpropion Do?

Diethylpropion acts as an appetite-suppressant by reducing hunger sensation levels within patients. It can also increase blood pressure and stimulate the central nervous system. This can, in turn, potentially increase the patient’s metabolic rate allowing them to burn fat at a higher rate than normal, however, this is usually combined with a calorie restrictive diet.

The purpose of a calorie restrictive diet in combination with this type of drug is to encourage the body to turn to its natural stores of fat to provide energy for the body throughout the day. This is ultimately what Diethylpropion actually does.

How Does Diethylpropion Work?

Diethylpropion stimulates neurons in the brain to release and maintain high levels of catecholamines – which are hormones produced by the adrenal glands, which sit on top of the kidneys – including dopamine and norepinephrine resulting in a suppression of hunger signals and appetite.

What Are The Side-Effects Of Diethylpropion?

Here are some side effects experienced by users, however, you may experience other unknown side effects.

Some potential side effects of taking Diethylpropion are: 

  • Severe headache
  • Slurred speech
  • Seizure
  • Weakness on one side of the body
  • Vision changes (e.g., blurred vision)
  • Dizziness
  • Dry mouth
  • Difficulty sleeping
  • Irritability
  • Nausea
  • Vomiting
  • Diarrhea
  • Constipation
  • Irregular heartbeat
  • Mood changes

Do Not Take Diethylpropion If:

  • You have suffered from blood vessel disease, high blood pressure, nervous, anxious, or tense state, glaucoma, overactive thyroid disease, or structure problems of the heart or other heart problems.
  • If you are pregnant and/or breast-feeding: Not recommended for use by pregnant or lactating women.
  • If you’re a child under the age of 18: Not intended for use by persons under the age of 18.

Diethylpropion Dosages

This will be determined by the prescribing medical practitioner.

Is Diethylpropion Prescription-Only?

You will need to obtain a prescription from a medical practitioner, as well as agree to a calorie restrictive diet and exercise regime, only if traditional methods of dieting and exercise have shown no response.

Can I Take Diethylpropion With Other Medication? 

This is NOT recommended without consulting a qualified medical practitioner.

Can I Take Diethylpropion With Other Supplements?

 This is NOT recommended without consulting a qualified medical practitioner.

Is Diethylpropion Safe?

Diethylpropion has been through numerous clinical trials and has been deemed as safe to consume for weight loss, however, it does increase blood pressure which could potentially lead to health problems.

Diethylpropion, was associated with an increased risk of developing pulmonary hypertension which can be fatal, however, this is very rare.

Has Diethylpropion Caused Deaths?

There have not been any deaths linked to this medication, however, an overdose could result in serious cardiovascular problems, or death.

Does Diethylpropion Actually Work?

A recent study carried out in 2015 and published in the International Journal of pharmacology and therapeutics documented the results of a clinical trial to evaluate the safety and efficiency of amfepramone (Diethylpropion).

The study took 156 volunteers with a body mass index greater than 30kg/m2 and less than 40kg/m2. Over a period of 6 months they were prescribed a 75mg daily does of amfepramone. Participants, on average, saw a drop in overall weight between 5% – 10% of total body mass. [1]

In this specific group of people, the drug did actually provide significant results.


Diethylpropion is a drug similar to amphetamine in that it stimulates the central nervous system, increases blood pressure, and suppresses appetite. In clinical trials, the drug has delivered significant results in terms of some patients losing up to 10% of their overall body fat, however, this drug is only prescribed to patients with a body mass index of 30kg/m2 or over, and must be used in conjunction with a calorie restrictive diet, and exercise program.

This drug will only be prescribed if the patient has not responded to traditional dieting and exercise.

Whilst it has been deemed safe to use over short periods of time to help tackle obesity, it is not a long-term solution for weight loss. It is important to note that this drug also stimulates the central nervous systems which could lead to other adverse, and unknown side effects.

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This article has been reviewed and fact-checked by a certified nutritionist, and only uses information from credible academic sources.