Myricetin is listed as a flavonoid within the broader class of polyphenol compounds.
This is naturally found in cruciferous vegetables, chia seeds, pistachio nuts, blueberries, peppers, garlic, and even red wine.
Most of the research on myricitin is to investigate its antioxidant properties and effects on bone health.
Due to the structural similarities, myricetin if often compared to other beneficial flavonoids such as kaempferol and quercetin.
Myricetin Health Benefits
May Increase Longevity
Myricetin has been noted in animal studies to prolong average and maximal lifespan by ~20%, which is comparatively longer than other tested flavanols (quercetin, kaempferol, and naringenin) .
The way it can achieve this effect is by reducing oxidative stress to the mitochondria, and thus avoiding chronic inflammation and cell damage which are the main drivers of aging.
It seems to be able to do this by activating specific transcription factors that modulate the genes involved in longevity and oxidative stress responses .
Lab studies also show that myricetin can induce the enzyme glutathione S-transferase, which has been suggested to protect cells against free-radicals .
This is critical for the prevention of cardiovascular diseases as it can inhibit the oxidation of LDL, that would typically represent the first key step in developing plaque on arterial walls .
To note, myricetin possesses greater antioxidant properties compared to other flavonoids due to its chemical structure (3 hydroxyl groups on the B ring) .
However, it is very important to understand that myricetin has the ability to be a prooxidant depending on the context of the system it is in, such as when it is in the presence of copper. On many occasions myricetin has undergone spontaneous oxidation, and it is not yet known whether this has the potential harm to cause harm.
May Be An Antidiabetic Agent
An antidiabetic substance is one that helps a person control the level of glucose (sugar) in the blood.
When myricetin is injected into animals, it has shown to decrease blood glucose levels in a dose-dependent manner and ameliorate the adverse effects of metabolic syndrome .
The mechanism of action is hypothesized to be by increasing the availability of glucose transporters in the blood (such as GLUT4), increasing insulin sensitivity, and by increasing the conversion of glucose into glycogen within muscle tissue . All these changes are ultimately effective at removing glucose from the blood and delivering it to lean body tissue.
There is limited data on humans, although the Finnish Mobile Clinic Health Examination Survey found that the higher the myricetin content of the diet, the lower the risk of type 2 diabetes . However, correlation does not equal causation and more stringent tests are needed to assess this relationship.
May Improve Bone Health
Lab studies have demonstrated that myricetin is able to prevent oxidative damage specifically in osteoblasts (bone cells) and potentially protect against osteoporosis by this mechanism and others such as increased calcium deposition .
This is thought to be due to increasing the production of parathyroid hormone. This is a hormone secreted by the parathyroid glands that is important in the bone remodelling process where bone tissue is continuously resorbed and rebuilt.
Myricetin Safety and Side Effect Information
Research hasn’t highlighted any serious safety concerns from taking myricetin.
The only side effect to note with myricetin supplementation is minor skin, eye, and respiratory irritation .
If you are prone to issues in any of these areas, it is advised to consult your doctor before taking myricetin.
Myricetin is a flavonoid found in many fruits and vegetables.
The current research on the compound shows evidence that it is a good antioxidant with the potential to increase longevity, although this has only yet been proven in animals.
Other potential uses are its role in preventing diabetes and bone-related issues.
Myricetin is deemed a safe supplement by most researchers, however at present there is a lack of supporting data to advise its use.